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pentobarbital will lessen the level or result of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers lessens plasma concentration of abemaciclib and its metabolites.Barbiturates are remedies that trigger you to take it easy or feel dr